Protamine Sulfate (Last Updated - 3/14/2005)
-heparin antidote
-used in pts. with life-threatening bleeds who are on heparin tx
-Mechanism:
-reverses effex by binding & neutralizing heparin
-Dosing / Admin:
-1 mg/100 units of heparin remaining in pt. @ slow IV rate of 50 mg/10mins
-Cautions:
-anaphylaxis in ~1% of diabetics on protamine-containing insulin:
-Ex.) NPH or protamine-zinc insulin
-Side Effex:
A) pulmonary vasoconstriction
B) RV dysfunction
C) systemic hypotension
D) transient neutropenia
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References:
Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.